Pathophysiological mechanisms of hepatic encephalopathy

Biochemical mechanisms of hepatic encephalopathy.

Clinical and Pathophysiological Characteristics of Cirrhotic Patients with Grade 1 and Minimal Hepatic Encephalopathy

BACKGROUND AND AIMS EASL/AASLD hepatic encephalopathy (HE) guidelines proposed the alternative use of the term 'Covert HE' combining minimal HE (mHE) and Grade 1 HE into a single entity. However, longitudinal data to indicate that these are indeed a single entity are lacking. The aims of this study were to determine whether the occurrence of complications of cirrhosis requiring hospital admissi...

Hepatic encephalopathy

Hepatic encephalopathy (HE) is a reversible syndrome of impaired brain function occurring in patients with advanced liver diseases. The precise pathophysiology of HE is still under discussion; the leading hypothesis focus on the role of neurotoxins, impaired neurotransmission due to metabolic changes in liver failure, changes in brain energy metabolism, systemic inflammatory response and altera...

Hepatic Encephalopathy

The liver is the most important organ for the well-functioning of other organs because of its vital role in nutrition, metabolism and secretion. Any disturbance in normal homeostasis of liver as it happens in acute liver failure (ALF) and chronic liver disease (cirrhosis) will lead to extra hepatic manifestations of liver disease, among them one is encephalopathy. And this encephalopathy caused...

Hepatic Encephalopathy

Hepatic encephalopathy (HE) is a brain disorder caused by chronic liver failure, particularly in alcoholics with cirrhosis, which results in cognitive, psychiatric, and motor impairments. In these patients, the number of functional liver cells is reduced, and some blood is diverted around the liver before toxins are removed. As a result, toxins such as ammonia and manganese can accumulate in th...